N5017

Sigma

 

Neuropeptide Y human

≥95% (HPLC), powder, synthetic

Synonym:hNPY, NPY
Amino Acid Sequence:Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
CAS Number:90880-35-6
Linear Formula:C189H285N55O57S
Molecular Weight:4271.68
MDL number:MFCD00212432

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Description

Biochem/physiol ActionsVasoconstrictor; brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Properties

biological sourcesynthetic
assay≥95% (HPLC)
formpowder
color white
solubilityH2O: 1 mg/mL
Gene Informationhuman ... NPY(4852)
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

References

referenceColmers, W.F., and Bleakman, D., Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17, 373-379, (1994)
 Billington, C.J., and Levine, A.S., Hypothalamic neuropeptide Y regulation of feeding and energy metabolism. Curr. Opin. Neurobiol. 2, 847-851, (1992)
 Kalra, S.P., and Horvath, T.L., Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite. Ann. N.Y. Acad. Sci. 863, 236-240, (1998)
 Sun, L., et al., Regulation of K+ and Ca2+ channels by a family of neuropeptide Y receptors. J. Pharmacol. Exp. Ther. 284, 625, (1998)
 Beech, D.J., Actions of neurotransmitters and other messengers on Ca2+ channels and K+ channels in smooth muscle cells. Pharmacol. Ther. 73, 91, (1997)
 Holst, J.J., et al., On the regulatory functions of neuropeptide Y (NPY) with respect to vascular resistance and exocrine and endocrine secretion in the pig pancreas. Acta Physiol. Scand. 136, 519-526, (1989)